Isoniazid 300mg Tablet

All Details About Isoniazid 300mg Tablet

Find out detailed description, uses, directions of use, side effects, warnings and precautions, frequently asked questions about Isoniazid 300mg Tablet

Description:

Isoniazid 300mg Tablet is an antibiotic used for the treatment and prevention of tuberculosis (TB) and inactive (latent) TB (a serious infection caused by bacteria that affects the lungs and in certain cases other parts of the body). It works by killing the bacteria that cause tuberculosis.

Isoniazid 300mg Tablet should be used in the dose and duration as advised by your doctor. It is to be taken on an empty stomach. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early can result in treatment failure and increase the side effects too. Do not take a double dose to make up for a missed dose. Simply take the next dose as planned.

Some common side effects of this medicine include tingling and numbness of feet and hand (peripheral neuropathy). Inform your doctor if you notice signs of jaundice, i.e., yellowing of eyes or skin, dark urine, stomach pain, or joint pain. You may also develop hepatitis (viral infection of the liver) or increased liver enzymes as side effects of this medicine. Please consult your doctor, as these side effects require medical attention and need dose modification.

Your doctor may monitor your liver function while on treatment with this medicine. Avoid drinking alcohol as this may have additional adverse effects on the liver. Pregnant or breastfeeding women should consult their doctor before using this medicine.

Uses:

Tuberculosis (TB)

Directions For Use:

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Isoniazid 300mg Tablet is to be taken on an empty stomach.
Avoid Isoniazid 300mg Tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.

Side Effects:

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Ordinary side effects of Isoniazid

Peripheral neuropathy (tingling and numbness of feet and hand)
Hepatitis (viral infection of liver)
Skin rash
Lethargy
Increased liver enzymes

Warning & Precautions:

Alcohol

UNSAFE

Consumption of alcohol with Isoniazid 300mg Tablet may cause a disulfiram-like reaction, leading to symptoms such as flushing, increased heart rate, low blood pressure, nausea, lightheadedness, and severe headache.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Isoniazid 300mg Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

SAFE IF PRESCRIBED

Available human data suggest that the drug does not pass into breast milk in clinically significant amounts and is unlikely to harm the infant.

Driving

UNSAFE

Isoniazid 300mg Tablet may cause side effects that could affect your ability to drive.
Isoniazid 300mg Tablet can cause fits, mental health problems and optic neuritis (inflammation of the optic nerve that may cause loss of vision.) This may affect your driving ability.

Kidney

SAFE IF PRESCRIBED

Isoniazid 300mg Tablet is safe to use in patients with kidney disease. No dose adjustment is recommended.
However, talk to your doctor if you have any underlying kidney disease.

Liver

CAUTION

Isoniazid 300mg Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.
Employ of Isoniazid 300mg Tablet is not recommended in patients with severe liver disease.

FAQs:

Is Isoniazid 300mg Tablet an antibiotic?

Isoniazid 300mg Tablet is an antibiotic used in the prevention and treatment of tuberculosis or TB (a serious infection caused by bacteria that affects the lungs and in certain cases other parts of the body)

Is Isoniazid 300mg Tablet chemotherapy/chemotherapy drug?

Isoniazid 300mg Tablet is a primary antibiotic used for treatment of tuberculosis. Do not confuse it with chemotherapy or chemo drugs used for the treatment of cancer

Is Isoniazid 300mg Tablet bacteriostatic or bactericidal?

Isoniazid 300mg Tablet is a bacteriostatic antibiotic. It stops or suppresses growth of tuberculosis causing bacteria by interfering with the formation of protective outer covering (cell wall) which is essential for their growth

Is Isoniazid 300mg Tablet safe?

Affirmative. Isoniazid 300mg Tablet is safe if used at prescribed doses for the prescribed duration as advised by your doctor

Is Isoniazid 300mg Tablet a MAOI?

Isoniazid 300mg Tablet has very weak inhibitory activity on enzymes monoamine oxidases (MAO); however it is not used as a monoamine oxidase inhibitor (MAOI)

Is Isoniazid 300mg Tablet a sulfa drug?

No. The chemical structure and mechanism of action of Isoniazid 300mg Tablet is different from sulfa drugs

Is Isoniazid 300mg Tablet an inducer or inhibitor?

Isoniazid 300mg Tablet is an inhibitor (decreases activity) of an important liver enzyme system that is responsible for the final processing and elimination of several drugs from the body

Can I take isoniazid with ibuprofen/Benadryl/Nyquil/Aleve/Mucinex/amoxicillin?

There no known serious drug interactions of isoniazid with ibuprofen, paracetamol (trade name: Tylenol), naproxen (trade name: Aleve), amoxicillin or any active drug present in Nyquil or Mucinex. Please inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects

Does Isoniazid 300mg Tablet cause weight loss/weight gain/hair loss/diarrhea/affect menstruation?

Alters in body weight (gain/loss), hair loss, diarrhea or changes in menstruation are not among the known side effects of Isoniazid 300mg Tablet. You may experience few of these side effects while on multi drug (including Isoniazid 300mg Tablet) treatment for tuberculosis

Does Isoniazid 300mg Tablet cause acne/make you tired/cause constipation?

You may experience unusual tiredness, constipation or acne while on treatment with Isoniazid 300mg Tablet. Please inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects

Does Isoniazid 300mg Tablet affect birth control?

Isoniazid 300mg Tablet has no known interaction with commonly used oral contraceptives (birth control pills). However, multidrug treatment for tuberculosis contains active drug rifampin that decreases the effectiveness of oral contraceptives and hampers birth control.

Written by:
Dr. T. Sharmila Krishna
M.B.B.S., MD (Biochemistry)

Reviewed by:
Dr. Sureshbabu Yadav
M.B.B.S., DIP.DIAB, F.R.S.H

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