Zolfresh 12.5mg Tablet ER

Last Updated: December 5th, 2025

Zolfresh 12.5mg Tablet ER is a product of Abbott

Composition: Zolpidem (12.5mg)

₹ 222.33

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All Details About Zolfresh 12.5mg Tablet ER

Find out detailed description, uses, directions of use, side effects, warnings and precautions, frequently asked questions about Zolfresh 12.5mg Tablet ER

Description:

Zolfresh 12.5mg Tablet ER is used for short-term treatment of insomnia. It reduces sleep onset time and frequent awakening at night. This medicine improves sleep maintenance and therefore ensures sound sleep.

Zolfresh 12.5mg Tablet ER should be taken on an empty stomach, preferably just before going to bed. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor as it is habit-forming. Do not stop taking it suddenly without talking to your doctor as it may worsen your symptoms.

Some common side effects of this medicine include memory loss, hallucinations, agitation, headache, vertigo, diarrhea, nausea, vomiting, and back pain. It may also cause fatigue, stomach pain, double vision, and depression. However, these are temporary and resolve on their own after some time. Please consult your doctor if these bother you or do not away.

Zolfresh 12.5mg Tablet ER also causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you, and do not take alcohol with it as it may worsen the dizziness. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, hallucinations, or suicidal thoughts while taking this medicine.

Earlier taking Zolfresh 12.5mg Tablet ER, inform your doctor about all other medicines that you are taking, so that your doctor can advise if taking this medicine is right for you. Consult your doctor before taking this medicine if you are suffering from any liver or kidney problems. You should avoid smoking and alcohol while using this medicine. Pregnant and breastfeeding mothers should not use this medicine. However, if the need arises, please consult your doctor before using it.

Uses:

Insomnia

Directions For Use:

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zolfresh 12.5mg Tablet ER is to be taken on an empty stomach.

Side Effects:

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Ordinary side effects of Zolfresh

Dizziness
Sleepiness
Diarrhea
Drowsiness

Warning & Precautions:

Alcohol

UNSAFE

Do not drink alcohol while you are taking this medicine. Zolfresh 12.5mg Tablet ER may cause excessive drowsiness when taken with alcohol.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Zolfresh 12.5mg Tablet ER during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

SAFE IF PRESCRIBED

Available human data suggest that the drug does not pass into breast milk in clinically significant amounts and is unlikely to harm the infant.

Driving

UNSAFE

Zolfresh 12.5mg Tablet ER may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

SAFE IF PRESCRIBED

Zolfresh 12.5mg Tablet ER is safe to use in patients with kidney disease. No dose adjustment is recommended.
However, inform your doctor if you have any kidney disease.

Liver

CAUTION

Zolfresh 12.5mg Tablet ER should be used with caution in patients with liver disease. Dose adjustment may be needed.
Zolfresh 12.5mg Tablet ER is generally started at a low dose in patients with mild to moderate liver disease and is not recommended in patients with severe liver disease.

FAQs:

Does Zolfresh 12.5mg Tablet ER make you high?

Zolfresh 12.5mg Tablet ER produces a calming effect on the brain and induces sleep. This calming effect may be perceived as pleasant or feeling high by some individuals. On prolonged use, Zolfresh 12.5mg Tablet ER may also make an individual dependent such that they are not be able to sleep or function normally without taking it.

Does Zolfresh 12.5mg Tablet ER have paracetamol (acetaminophen) or aspirin in it?

No, Zolfresh 12.5mg Tablet ER does not have paracetamol (acetaminophen) or aspirin in it.

Can I take Zolfresh 12.5mg Tablet ER with prednisone?

No drug-drug interactions have been found Zolfresh 12.5mg Tablet ER taken with prednisone. However always consult with your doctor before taking these medicines together.

Does Zolfresh 12.5mg Tablet ER help with anxiety?

Zolfresh 12.5mg Tablet ER is used to treat insomnia, which may help ease anxiety in some patients, although doctors do not prescribe Zolfresh 12.5mg Tablet ER for anxiety alone because it does not work in the same manner as other sedatives anti-anxiety drugs

Does Zolfresh 12.5mg Tablet ER have abuse potential?

Affirmative, Zolfresh 12.5mg Tablet ER has abuse potential. However, it is more commonly seen in patients with a history of drug abuse, alcohol consumption, and drug addiction. Therefore, doctors should carefully take history of drug abuse from the patient. Moreover, patients with a history of drug abuse or addiction should be closely monitored during Zolfresh 12.5mg Tablet ER therapy.

What are the symptoms of an overdose of Zolfresh 12.5mg Tablet ER?

The symptoms of Zolfresh 12.5mg Tablet ER overdose include drowsiness, confusion, problems with coordination, floppy muscles, slow or difficult breathing, and even coma (loss of consciousness for a period of time).

What should I should avoid when taking Zolfresh 12.5mg Tablet ER?

Zolfresh 12.5mg Tablet ER can make you drowsy during the daytime and also decrease your mental alertness. Therefore, you should not drive or operate heavy machinery until and unless you know how Zolfresh 12.5mg Tablet ER affects you. Do not drink alcohol while you are taking Zolfresh 12.5mg Tablet ER. Alcohol can make the side effects of Zolfresh 12.5mg Tablet ER even worse.

Who should not take Zolfresh 12.5mg Tablet ER?

You should not take Zolfresh 12.5mg Tablet ER if you are allergic to it or any of its ingredients. You should also avoid Zolfresh 12.5mg Tablet ER if you have a history of depression, mental illness, or suicidal thoughts. A person having a history of drug or alcohol abuse or addiction, having kidney or liver disease, having a lung disease or breathing problems should avoid Zolfresh 12.5mg Tablet ER. Also, its consumption is not recommended if you are pregnant, planning to become pregnant, or breastfeeding.

Can I take Zolfresh 12.5mg Tablet ER with food?

No, do not take Zolfresh 12.5mg Tablet ER with or shortly after a heavy, high-fat meal. Zolfresh 12.5mg Tablet ER may not work well if it is taken with high-fat foods.

Can Zolfresh 12.5mg Tablet ER be taken everyday? How long should it be taken?

Zolfresh 12.5mg Tablet ER is used for short-term (2-4 weeks) treatment of insomnia (difficulty falling asleep). It should be taken exactly as prescribed by the doctor. The dose and duration of treatment should not be exceeded else it may lead to dependence (addiction towards medicine).

Does Zolfresh 12.5mg Tablet ER cause dry mouth and affect weight?

Affirmative, dry mouth is a common side effect of Zolfresh 12.5mg Tablet ER, whereas weight gain is less common with Zolfresh 12.5mg Tablet ER. If you experience weight gain, it could be due to increased appetite.

How long does Zolfresh 12.5mg Tablet ER take to start working?

Zolfresh 12.5mg Tablet ER starts working as soon as you take it and may make you very sleepy. You may remain sleepy for some time after you take the medication. Plan to go to bed right after you take Zolfresh 12.5mg Tablet ER and to stay in bed for 7 to 8 hours. Do not take Zolfresh 12.5mg Tablet ER if you will be unable to go to bed right away and remain asleep for 7 to 8 hours after taking the medication.

What are the withdrawal symptoms of Zolfresh 12.5mg Tablet ER?

Do not stop taking Zolfresh 12.5mg Tablet ER without talking to your doctor. If you suddenly stop taking Zolfresh 12.5mg Tablet ER, you may experience withdrawal symptoms such as unpleasant feelings, stomach and muscle cramps, vomiting, sweating, shakiness, and rarely, seizures.

How can I improve my sleep without medicines?

You can improve your sleep by avoiding caffeine and nicotine, especially late in the day. Avoid exercise during the four hours before bedtime; daily exercise is beneficial to sleep, but can interfere if done close to bedtime. Avoid large meals in the evening. Avoid taking naps. Go to sleep and wake up at the same time each day. Retain the bedroom as dark as possible and maintain a comfortable temperature. Set aside a time to relax before bed and use relaxation techniques.

What is insomnia?

Insomnia is a common sleep disorder. People with insomnia experience trouble in falling asleep, staying asleep, or both. As a result, they may get too little sleep or have poor-quality sleep, and they may not feel refreshed after waking up.

What are the causes of insomnia?

Insomnia can be of two types- primary or secondary. In primary insomnia, the cause is not known. It can be triggered by life-style changes including long-lasting stress and emotional upset. Whereas, secondary insomnia can be caused due to various reasons such as certain medical conditions (depression, anxiety, post-traumatic stress disorder, Alzheimer's disease, and Parkinson's disease), medicines, sleep disorders, and substances (caffeine and other stimulants, tobacco and other nicotine products, and alcohol).

Written by:
Dr. T. Sharmila Krishna
M.B.B.S., MD (Biochemistry)

Reviewed by:
Dr. Sureshbabu Yadav
M.B.B.S., DIP.DIAB, F.R.S.H

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