Xagly M 50mg/500mg Tablet 15.0 tablets in 1 strip

Last Updated: April 15th, 2026

Xagly M 50mg/500mg Tablet is a product of Genetic Pharma

Composition: Sitagliptin (50mg) + Metformin (500mg)

Pack of 15 tablet

₹ 281.25

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Limited Stock

All Details About Xagly M 50mg/500mg Tablet

Find out detailed description, uses, directions of use, side effects, warnings and precautions, frequently asked questions about Xagly M 50mg/500mg Tablet

Description:

Xagly M 50mg/500mg Tablet is a combination of two medicines that control high blood sugar levels in people with type 2 diabetes mellitus. This helps prevent serious complications of diabetes, such as kidney damage and blindness and may reduce your chances of having a heart attack or stroke.

Xagly M 50mg/500mg Tablet may be prescribed alone or along with other diabetes medications. It works best when used along with a healthy diet and regular exercise. Your dose will depend on your condition, blood sugar levels, and other medicines you are taking. Taking it with meals helps to reduce the chances of developing an upset stomach.

To get the most benefit, you should take it regularly, at the same time each day, and you should not stop unless your doctor recommends it. It is important to stay on the diet and exercise program recommended by your doctor while taking this medicine. Your lifestyle plays a big part in controlling diabetes.

The most common side effects of taking Xagly M 50mg/500mg Tablet include diarrhea, upper respiratory tract infection, and headache. Low blood sugar level (hypoglycemia) is a possible side effect if you are also taking other diabetes medicines like insulin or sulfonylurea. Hence, you need to know how to recognize and deal with it.

This medicine is not suitable for everyone. Earlier taking it, you should let your doctor know if you have ever had kidney, liver, or heart disease, problems with your pancreas, or if you drink a lot of alcohol. Pregnant or breastfeeding women should also consult their doctor before taking this medicine. Some other medicines may affect Xagly M 50mg/500mg Tablet, so tell your doctor about all the other medicines you are taking to ensure you are safe. You should try to avoid drinking alcohol as it lowers blood glucose. Your doctor will check your kidney function and blood sugar levels before and during treatment.

Uses:

Treatment of Type 2 diabetes mellitus

Directions For Use:

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Xagly M 50mg/500mg Tablet should be taken with or after food.

Side Effects:

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Ordinary side effects of Xagly M

Diarrhea
Upper respiratory tract infection
Headache

Warning & Precautions:

Alcohol

UNSAFE

It is unsafe to consume alcohol with Xagly M 50mg/500mg Tablet

Pregnancy

CONSULT YOUR DOCTOR

Information regarding the use of Xagly M 50mg/500mg Tablet during pregnancy is not available. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Xagly M 50mg/500mg Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

CAUTION

Xagly M 50mg/500mg Tablet may affect your driving ability if your blood sugar becomes too low or too high. Monitor your blood glucose and avoid driving if affected.

Kidney

CAUTION

Xagly M 50mg/500mg Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Employ of Xagly M 50mg/500mg Tablet is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine.

Liver

UNSAFE

Xagly M 50mg/500mg Tablet is unsafe to use in patients with liver disease and should be avoided.

FAQs:

What is Xagly M 50mg/500mg Tablet?

Xagly M 50mg/500mg Tablet is a combination of two medicines: sitagliptin and metformin. This medicine is used in the treatment of type 2 diabetes mellitus. It improves blood glucose levels in adults when taken along with a proper diet and regular exercise. Metformin lowers glucose production in the liver and improves insulin sensitivity. Sitagliptin inhibits the enzyme DPP4 and increases insulin release from the pancreas. This combination is not indicated for patients below 18 years of age.

What are the possible side effects of Xagly M 50mg/500mg Tablet?

The use of Xagly M 50mg/500mg Tablet is associated with common side effects like diarrhea, headache, and upper respiratory tract infection. Its use can also lead to serious but rare side effects like lactic acidosis. On long-term use, it can also lead to vitamin B12 deficiency.

Are there any specific conditions in which Xagly M 50mg/500mg Tablet should not be taken?

The use of Xagly M 50mg/500mg Tablet should be avoided in patients with known allergies to any of the components or excipients of this medicine. The use of this medicine should be avoided in patients with severe kidney impairment, liver impairment, congestive heart failure, lactic acidosis, or diabetic ketoacidosis.

Is it safe to take alcohol while I am taking Xagly M 50mg/500mg Tablet?

No, it is not safe to consume alcohol along with Xagly M 50mg/500mg Tablet, as it can increase the chances of lactic acidosis.

Can the use of Xagly M 50mg/500mg Tablet lead to lactic acidosis?

Affirmative, the use of Xagly M 50mg/500mg Tablet can lead to lactic acidosis. It is a medical emergency caused by the increased levels of lactic acid in the blood. It is also known as MALA (metformin-associated lactic acidosis). It is a rare side effect associated with the use of metformin. Therefore, it is avoided in patients with underlying kidney disease, elderly patients, or those who take large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, dizziness, tiredness, a feeling of cold in arms and legs, difficulty in breathing, nausea, vomiting, stomach pain, or a slow heart rate. If you have these symptoms, stop taking sitagliptin + metformin and immediately consult your doctor.

Can the use of Xagly M 50mg/500mg Tablet lead to vitamin B12 deficiency?

Affirmative, using Xagly M 50mg/500mg Tablet can cause vitamin B12 deficiency in the long term. It interferes with the absorption of vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems, as a result of which the patient can feel a tingling sensation and numbness in hands and feet, weakness, urinary problems, a change in mental status, and difficulty maintaining balance (ataxia). To avoid such problems, some researchers suggest an intake of vitamin B12 from outside sources at least once every year.

What are the instructions for storage and disposal of Xagly M 50mg/500mg Tablet?

Retain this medicine tightly closed in the container or pack it came in. Store it according to the instructions on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children, or other people.

Written by:
Dr. T. Sharmila Krishna
M.B.B.S., MD (Biochemistry)

Reviewed by:
Dr. Sureshbabu Yadav
M.B.B.S., DIP.DIAB, F.R.S.H

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