Resof Total 400mg/100mg Tablet 28.0 tablets in 1 bottle

Last Updated: December 13th, 2025

Resof Total 400mg/100mg Tablet is a product of Dr Reddy's Laboratories Ltd

Composition: Sofosbuvir (400mg) + Velpatasvir (100mg)

Pack of 28 tablet

₹ 18046.88

Note: MRP can vary depending up on batch!

*MRP inclusive of all taxes

All Details About Resof Total 400mg/100mg Tablet

Find out detailed description, uses, directions of use, side effects, warnings and precautions, frequently asked questions about Resof Total 400mg/100mg Tablet

Description:

Resof Total 400mg/100mg Tablet is a combination of two antiviral medicines. This prescription medicine is used in the treatment of chronic hepatitis C virus (HCV) infection. It fights against the viruses to resolve the infection.

Resof Total 400mg/100mg Tablet should be taken in the prescribed dose and duration. It can be taken with or without food, but take it at the same time daily. It is advised not to consume more than the recommended dose. It is important to inform your doctor if you have any health conditions such as liver or kidney disease. It is harmful to consume alcohol along with this medicine, so it is advised to limit or avoid alcohol. The course of the medicine should be completed for better results.

The common side effects of this medicine include fatigue, anemia, nausea, headache, insomnia, and diarrhea. You should drink plenty of fluid and eat a healthy diet to prevent or overcome the side effects. Earlier taking the medicine, inform your doctor if you are taking any other medicines or supplements.

Uses:

Treatment of Chronic hepatitis C virus (HCV) infection

Directions For Use:

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Resof Total 400mg/100mg Tablet may be taken with or without food.

Side Effects:

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Ordinary side effects of Resof Total

Headache
Diarrhea
Insomnia (difficulty in sleeping)
Anemia (low number of red blood cells)
Nausea
Chubbyigue

Warning & Precautions:

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Resof Total 400mg/100mg Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Information regarding the use of Resof Total 400mg/100mg Tablet during pregnancy is not available. Please consult your doctor.

Breast feeding

SAFE IF PRESCRIBED

Resof Total 400mg/100mg Tablet may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Driving

UNSAFE

Resof Total 400mg/100mg Tablet may cause side effects that could affect your ability to drive.
Resof Total 400mg/100mg Tablet, when taken together with other medicines for the treatment of hepatitis c infection, may produce dizziness, blurred vision and this may affect your ability to drive.

Kidney

CAUTION

Resof Total 400mg/100mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Limited information is available on the use of Resof Total 400mg/100mg Tablet in these patients. No dose adjustment is recommended in patients with mild to moderate kidney disease.

Liver

SAFE IF PRESCRIBED

Resof Total 400mg/100mg Tablet is safe to use in patients with liver disease. No dose adjustment is recommended.
However, inform your doctor if you have any kidney disease as regular monitoring of liver function tests may be advised in some patients while taking this medicine.

FAQs:

What is Resof Total 400mg/100mg Tablet used for?

Resof Total 400mg/100mg Tablet is used to treat chronic hepatitis C infection in adults and children 3 years and older. It works across all six main types of hepatitis C virus, is often combined with another medicine in difficult-to-treat cases.

Can Resof Total 400mg/100mg Tablet cure hepatitis C completely?

When taken as directed by your doctor, Resof Total 400mg/100mg Tablet is highly effective, with most patients achieving a sustained virologic response. This meaning the virus is not detectable in the blood twelve weeks after completing treatment.

Who should not take Resof Total 400mg/100mg Tablet?

People should not take Resof Total 400mg/100mg Tablet if they are allergic to sofosbuvir, velpatasvir, or any ingredient in the medicine, are taking certain other medicines that strongly interact, such as rifampicin, or St. John’s wort.

Can Resof Total 400mg/100mg Tablet cause serious allergic reactions?

Affirmative. Though rare, Resof Total 400mg/100mg Tablet can cause serious allergic reactions. Perceivek immediate medical help if you develop rash, swelling of the face or throat, trouble breathing, or severe dizziness.

Can Resof Total 400mg/100mg Tablet cause worsening of hepatitis B infection?

Affirmative. If you have had hepatitis B in the past, Resof Total 400mg/100mg Tablet may cause the virus to become active again. Your doctor will test you for hepatitis B before starting Resof Total 400mg/100mg Tablet treatment, monitor you closely if needed.

What are the serious side effects of Resof Total 400mg/100mg Tablet?

Earnest side effects of Resof Total 400mg/100mg Tablet include slow or irregular heartbeat, extreme tiredness, confusion, jaundice (yellowing skin or eyes), severe weakness, or unusual bleeding. Perceivek immediate medical attention if you experience any of these symptoms.

Is Resof Total 400mg/100mg Tablet safe for people with liver problems?

Affirmative, Resof Total 400mg/100mg Tablet is commonly used in patients with liver disease, including compensated cirrhosis (an early, often asymptomatic stage of cirrhosis where the liver is significantly scarred but still functioning well enough for the body to compensate for the damage). However, if you have decompensated cirrhosis, your doctor may prescribe Resof Total 400mg/100mg Tablet with other medicine, monitor you more closely.

Can Resof Total 400mg/100mg Tablet cause heart rhythm problems?

Affirmative. When Resof Total 400mg/100mg Tablet is taken with another medicine called amiodarone, it can cause dangerous slowing of the heart rate. Tolerants on amiodarone need close monitoring, especially at the start of treatment.

Written by:
Dr. T. Sharmila Krishna
M.B.B.S., MD (Biochemistry)

Reviewed by:
Dr. Sureshbabu Yadav
M.B.B.S., DIP.DIAB, F.R.S.H

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