Olbrace Plus 20mg/5mg Tablet 15.0 tablets in 1 strip

Last Updated: April 14th, 2026

Olbrace Plus 20mg/5mg Tablet is a product of HBC Lifesciences Pvt Ltd

Composition: Fluoxetine (20mg) + Olanzapine (5mg)

Pack of 15 tablet

₹ 165.94

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All Details About Olbrace Plus 20mg/5mg Tablet

Find out detailed description, uses, directions of use, side effects, warnings and precautions, frequently asked questions about Olbrace Plus 20mg/5mg Tablet

Description:

Olbrace Plus 20mg/5mg Tablet is a prescription medicine used in the treatment of depression associated with bipolar disorder. It works by increasing the level of chemical messengers in the brain, which improves mood and physical symptoms of depression.

Olbrace Plus 20mg/5mg Tablet may be taken with or without food. Take it at the same time each day, as this helps maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and do not miss a dose. This medication must not be stopped suddenly without talking to your doctor, as it may worsen your symptoms.

Some common side effects of this medicine include dryness in the mouth, weight gain, and disturbance in attention. It may also cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how this medicine affects you. However, these symptoms are temporary and usually resolve on their own. Please consult your doctor if these do not subside or bother you.

Earlier taking Olbrace Plus 20mg/5mg Tablet, inform your doctor if you are suffering from thyroid or kidney disease, epilepsy, Parkinson’s disease, glaucoma, or any heart disease. You should not take this medicine if you are under the influence of alcohol or any sleep-inducing, coughing, or allergy medication. You should avoid alcohol while taking Olbrace Plus 20mg/5mg Tablet, as it may worsen certain side effects.

Olbrace Plus 20mg/5mg Tablet can also lead to weight gain, eat a healthy, balanced diet, avoid snacking with high-calorie food, and exercise regularly. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.

Uses:

Depression associated with Bipolar disorder
Bipolar depression

Directions For Use:

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Olbrace Plus 20mg/5mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

Side Effects:

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Ordinary side effects of Olbrace Plus

Weight gain
Dryness in mouth
Edema (swelling)
Challengingy in paying attention
Chubbyigue
Increased appetite
Sedation
Sleepiness
Blurred vision

Warning & Precautions:

Alcohol

UNSAFE

It is unsafe to consume alcohol with Olbrace Plus 20mg/5mg Tablet.

Pregnancy

CONSULT YOUR DOCTOR

Olbrace Plus 20mg/5mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Olbrace Plus 20mg/5mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

UNSAFE

Olbrace Plus 20mg/5mg Tablet may cause side effects which could affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

Olbrace Plus 20mg/5mg Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Olbrace Plus 20mg/5mg Tablet may not be needed in these patients. Please consult your doctor.

Liver

CAUTION

Olbrace Plus 20mg/5mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Olbrace Plus 20mg/5mg Tablet may be needed. Please consult your doctor.

FAQs:

What is Olbrace Plus 20mg/5mg Tablet used for?

Olbrace Plus 20mg/5mg Tablet is used to treat depression in bipolar disorder (bipolar depression) and treatment-resistant depression (when other antidepressants haven’t worked). It combines an antidepressant (fluoxetine) and an antipsychotic (olanzapine) to help improve mood, sleep, appetite, and energy.

Can Olbrace Plus 20mg/5mg Tablet be used in children or elderly patients?

Olbrace Plus 20mg/5mg Tablet is not approved for children under 10 years of age and should be avoided in elderly people with dementia, as it increases the risk of death and stroke in such patients.

What are the serious side effects of Olbrace Plus 20mg/5mg Tablet I should know about?

During Olbrace Plus 20mg/5mg Tablet therapy, some serious side effects include suicidal thoughts (especially in younger people), severe allergic reactions (rash, swelling), high blood sugar or diabetes, unusual body movements (tardive dyskinesia), serotonin syndrome (confusion, sweating, fast heart rate), and seizures or fainting. Call your doctor right away if you notice any of these symptoms.

Does Olbrace Plus 20mg/5mg Tablet cause weight gain?

Affirmative. Weight gain and increased appetite are common side effects of Olbrace Plus 20mg/5mg Tablet. Regular weight checks are recommended during treatment.

Can I stop taking Olbrace Plus 20mg/5mg Tablet suddenly?

You should never stop taking Olbrace Plus 20mg/5mg Tablet suddenly. Doing so can lead to withdrawal symptoms like dizziness, mood swings, and flu-like feelings. Forever talk to your doctor before stopping.

What should I avoid while taking Olbrace Plus 20mg/5mg Tablet?

You should avoid consuming alcohol (increases drowsiness and blood pressure drops), operating vehicles or machinery if feeling sleepy, and other serotonin-boosting drugs unless approved by your doctor. Tell your doctor about all medications and supplements you take to avoid dangerous interactions.

Can Olbrace Plus 20mg/5mg Tablet affect my thinking or coordination?

Olbrace Plus 20mg/5mg Tablet may cause trouble thinking, drowsiness, or dizziness. Avoid driving or using heavy machinery until you know how it affects you.

Can Olbrace Plus 20mg/5mg Tablet affect my blood sugar or cholesterol levels?

Affirmative. Olbrace Plus 20mg/5mg Tablet can cause high blood sugar (even leading to diabetes) and high cholesterol or triglyceride levels. These should be monitored with blood tests during Olbrace Plus 20mg/5mg Tablet treatment.

How should I take Olbrace Plus 20mg/5mg Tablet?

Take Olbrace Plus 20mg/5mg Tablet exactly as prescribed, typically once daily in the evening with or without food. Swallow the tablets whole with water. Your doctor may start with a low dose and gradually increase it based on your response and tolerance.

How long does Olbrace Plus 20mg/5mg Tablet take to show results?

The exact time Olbrace Plus 20mg/5mg Tablet takes to show results is not known. However, some symptoms may improve within weeks, but full benefit often takes a few weeks to months of consistent use. Improvement in mood may take longer. You should continue taking it as prescribed even if you don't notice immediate improvements.

Can I drink alcohol while taking Olbrace Plus 20mg/5mg Tablet?

Alcohol should be avoided while taking Olbrace Plus 20mg/5mg Tablet, as it can worsen drowsiness and dizziness and may increase depression symptoms. Combining alcohol with Olbrace Plus 20mg/5mg Tablet can also impair judgment and increase the risk of dangerous behaviors.

What health monitoring is required during Olbrace Plus 20mg/5mg Tablet treatment?

Your doctor may advise regular health monitoring, including weight, blood pressure, blood sugar, and lipid profiles. Your doctor may also order periodic blood tests to check medication levels and monitor for metabolic changes or other side effects.

Written by:
Dr. T. Sharmila Krishna
M.B.B.S., MD (Biochemistry)

Reviewed by:
Dr. Sureshbabu Yadav
M.B.B.S., DIP.DIAB, F.R.S.H

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