Nex 400mcg Injection

Last Updated: April 9th, 2026

Nex 400mcg Injection is a product of Neon Laboratories Ltd

Composition: Naloxone (400mcg)

₹ 97.31

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All Details About Nex 400mcg Injection

Find out detailed description, uses, directions of use, side effects, warnings and precautions, frequently asked questions about Nex 400mcg Injection

Description:

Nex 400mcg Injection is an opioid antagonist. It is used for the treatment of opioid toxicity. It helps to reverse the depressant effect on breathing, and on other parts of the body. It also helps to determine if a patient has taken an overdose of opioids.

Nex 400mcg Injection is given as an injection into veins, muscle, or under the skin by a doctor or nurse. It is advisable not to self-administer the injection. Your doctor or nurse will train your family member or caregiver about how to inject the medicine in case of an emergency. It is advisable to follow your doctor's advice while being on the treatment.

The most common side effects of this medicine include injection site redness, dizziness, headache and increased or decreased blood pressure. Most of these usually go away within a short time of the injection. If you are bothered by them or they go on for longer, talk to your doctor or nurse. You should not drive if this medicine makes you feel dizzy.

Earlier taking it, tell your doctor if you have heart problems, high blood pressure, or high heart rate. This may affect your treatment. Pregnant or breastfeeding women should consult their doctor before taking this medicine. Some other medicines you are taking may interfere with it, so make sure your doctor knows about all the other medicines you are using.

Uses:

Opioid toxicity

Directions For Use:

Your doctor or nurse will give you this medicine. Compassionately do not self administer.

Side Effects:

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Ordinary side effects of Nex

Dizziness
Injection site redness
Decreased blood pressure
Headache
High blood pressure

Warning & Precautions:

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Nex 400mcg Injection. Please consult your doctor.

Pregnancy

SAFE IF PRESCRIBED

Nex 400mcg Injection is generally considered safe to use during pregnancy. Animal studies do not indicate harmful effects. However, there are limited human studies.

Breast feeding

SAFE IF PRESCRIBED

Available human data suggest that the drug does not pass into breast milk in clinically significant amounts and is unlikely to harm the infant.

Driving

UNSAFE

Nex 400mcg Injection may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Nex 400mcg Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Nex 400mcg Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.

FAQs:

What is Nex 400mcg Injection used for?

Nex 400mcg Injection is an emergency medicine used to rapidly reverse the life-threatening effects of an opioid overdose. It can quickly restore normal breathing in a person whose breathing has slowed down or stopped due to taking too many opioids.

How quickly does Nex 400mcg Injection start to work?

When given intravenously (IV), Nex 400mcg Injection works extremely fast, often within one to two minutes. If it is injected into a muscle (intramuscular) or under the skin (subcutaneous), it starts to work within about 2 to 5 minutes.

Where on the body should I give Nex 400mcg Injection?

For intramuscular auto-injectors of Nex 400mcg Injection, the best place to inject the medicine is into the middle of the outer thigh. You can even give the injection through clothing if you need to act quickly. Also, try to take the affected person to the hospital as soon as possible.

What happens if I give Nex 400mcg Injection to someone who has not taken opioids?

If you give Nex 400mcg Injection to someone who is unconscious for a reason other than an opioid overdose, it is unlikely to harm them. Since it is hard to be sure of the cause in an emergency, it is always safer to administer this medicine if an opioid overdose is suspected.

Will one dose of Nex 400mcg Injection be enough?

Sometimes, a single dose of Nex 400mcg Injection is not enough, or the person may respond and then relapse into respiratory depression. It may be necessary to give additional doses of this medicine every 2 to 3 minutes until emergency medical help arrives or the person is breathing normally again.

What should I do if the person does not wake up after Nex 400mcg Injection?

If the person does not respond to Nex 400mcg Injection, you must be prepared to perform other life-saving measures. This could include rescue breathing or starting CPR if you are trained to do so, while you wait for paramedics to arrive.

Written by:
Dr. T. Sharmila Krishna
M.B.B.S., MD (Biochemistry)

Reviewed by:
Dr. Sureshbabu Yadav
M.B.B.S., DIP.DIAB, F.R.S.H

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