Depalep 250mg Tablet ER 10.0 tablet er in 1 strip

Last Updated: October 8th, 2025

Depalep 250mg Tablet ER is a product of Werke Healthcare

Composition: Divalproex (250mg)

Pack of 10 tablet

₹ 166.88

*Note: MRP can vary depending up on batch!

*MRP inclusive of all taxes

All Details About Depalep 250mg Tablet ER

Find out detailed description, uses, directions of use, side effects, warnings and precautions, frequently asked questions about Depalep 250mg Tablet ER

Description:

Depalep 250mg Tablet ER is a medication used to treat epilepsy, seizures, bipolar disorder, mania, trigeminal neuralgia, and migraines. It works by stabilizing brain activity. Forever use it under medical supervision for safe and effective treatment.

Depalep 250mg Tablet ER may be used alone or in combination with other medicines. Your doctor will determine the appropriate dose and frequency to effectively control your symptoms. You can take this medicine with or without food, but for the best results, take it at the same time each day. It usually takes a couple of weeks to work. It is important to take this medicine regularly and for as long as you are advised, even if you feel well. Missing doses may trigger seizures, and if you stop, your condition may get worse. It should never be stopped suddenly.

The most common side effects of Depalep 250mg Tablet ER include headache, constipation, nausea, vomiting, dizziness, weight gain, rash, back pain, and abdominal pain. Most of these are not serious. Continue taking the medicine, but consult your doctor if these side effects persist or become bothersome. However, if you notice a skin rash or redness, tell your doctor straight away. Long-term treatment with this medicine can cause osteoporosis (reduced bone mass) and increase your risk of breaking a bone. Also, Depalep 250mg Tablet ER may rarely lead to suicidal thoughts and behaviors. If your mood becomes depressed, tell your doctor.

Depalep 250mg Tablet ER may not be suitable for everybody. Earlier using it, tell your doctor if you have ever had heart problems, kidney or liver disease, difficulty urinating, depression, or suicidal thoughts. Some medicines can interfere with it and should not be taken together, so tell your doctor about all the medicines you are taking to make sure it is safe for you. If you are pregnant, do not take this medicine without asking your doctor. Avoid drinking alcohol, as it may enhance certain side effects and increase the risk of seizures. You may need frequent blood tests to help your doctor make sure you are taking the right dose both before you start and while you are using it.

Uses:

Directions For Use:

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Depalep 250mg Tablet ER may be taken with or without food, but it is better to take it at a fixed time.

Side Effects:

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Ordinary side effects of Depalep

Abdominal pain
Accidental injury
Hair loss
Blurred vision
Memory loss
Decreased appetite
Weakness
Abnormality of voluntary movements
Posterior pain
Bronchitis (inflammation of the airways)
Constipation
Depression
Diarrhea
Double vision
Dizziness
Indigestion
Pantingness
Ecchymosis (discoloration of the skin resulting from bleeding underneath)
Emotional lability
Fever
Influenza like syndrome
Headache
Increased appetite
Insomnia (difficulty in sleeping)
Nausea
Tenseness
Nystagmus (involuntary eye movement)
Peripheral edema
Sore throat
Rash
Inflammation of the nose
Sleepiness
Reviseed thinking
Low blood platelets
Ringing in ear
Tremors
Vomiting
Weight gain
Weight loss

Warning & Precautions:

Alcohol

UNSAFE

Depalep 250mg Tablet ER may cause excessive drowsiness with alcohol.

Pregnancy

CONSULT YOUR DOCTOR

Depalep 250mg Tablet ER is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding

CAUTION

Depalep 250mg Tablet ER should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.

Driving

UNSAFE

Depalep 250mg Tablet ER may cause side effects which could affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

Depalep 250mg Tablet ER is safe to use in patients with kidney disease. No dose adjustment of Depalep 250mg Tablet ER is recommended.

Liver

UNSAFE

Depalep 250mg Tablet ER is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.

FAQs:

What happens if I stop taking Depalep 250mg Tablet ER?

You should not stop taking Depalep 250mg Tablet ER without consulting your doctor. The dose of Depalep 250mg Tablet ER should be reduced gradually and eventually can be stopped under the supervision of a doctor or specialist. Suddenly stopping the medication may trigger seizures or lead to the recurrence of symptoms.

Is Depalep 250mg Tablet ER a mood stabilizer?

Affirmative, Depalep 250mg Tablet ER can sometimes be used as a mood stabilizer. It is given in patients who experience rapid changes in their mood. It works by calming the hyperactivity of the brain during mood changes.

Can Depalep 250mg Tablet ER cause weight gain?

Affirmative, Depalep 250mg Tablet ER may cause weight gain. The gain in weight could be due to an increase in hunger. Retain a check on your diet and exercise regularly to prevent any weight gain. If you are have concerns related to weight gain, consult your doctor.

Does Depalep 250mg Tablet ER make you sleepy?

Affirmative, Depalep 250mg Tablet ER may make you feel sleepy. Avoid driving or other work that requires mental focus until you know how it affects you.

Does Depalep 250mg Tablet ER cause hair loss?

Affirmative, Depalep 250mg Tablet ER may cause hair loss. However, it is only for a short time and is usually dose-related. Consult your doctor if the hair loss bothers you or persists for a longer duration.

Can Depalep 250mg Tablet ER damage my liver?

Affirmative, Depalep 250mg Tablet ER can cause damage to the liver. The risk is more likely to occur during the first 6 months of starting the treatment with Depalep 250mg Tablet ER. Symptoms of liver damage may include nausea or vomiting, loss of appetite, stomach pain, dark-colored urine, facial swelling, yellowing of the skin, or white eyes. Therefore, it is important to have liver function tests done before starting the medicine. Tests should be done periodically during the first 6 months of therapy, especially in those who are likely to be at risk and those with a prior history of liver disease.

Can I take alcohol while I am taking Depalep 250mg Tablet ER?

Avoid alcohol consumption while you are on treatment with Depalep 250mg Tablet ER. Taking alcohol with this medicine may make you feel more drowsy, light headed or dizzy.

What are the laboratory tests recommended before taking Depalep 250mg Tablet ER?

The doctor may suggest blood tests before starting the treatment with Depalep 250mg Tablet ER. The tests may include blood cell count, including platelet count, bleeding time, and coagulation tests. These tests are also advised to avoid any spontaneous bruising or bleeding. In addition to this, liver function tests are advised before therapy. It is recommended to periodically monitor liver function during the first 6 months of therapy, primarily in those who seem most at risk and those with a prior history of liver disease.

What should be done if I start experiencing abdominal pain, nausea and anorexia?

If you experience acute, severe abdominal pain along with nausea and vomiting, it may be due to pancreatitis. Immediately consult your doctor in case you experience these symptoms. Your doctor may get your levels of serum amylase checked. In case the test shows positive results for pancreatitis, the medication should be stopped immediately.

How to check for overdose of Depalep 250mg Tablet ER?

An overdose of Depalep 250mg Tablet ER may cause headaches, blurred eyesight due to the pupils of the eyes becoming smaller, lack of reflexes, confusion, and tiredness. You may also experience weak or “floppy” muscles, fits (seizures), loss of consciousness, behavioral changes, and breathing difficulties such as fast breathing, shortness of breath, or chest pain. Immediate medical assistance is required in case of overdose.

Written by:
Dr. T. Sharmila Krishna
M.B.B.S., MD (Biochemistry)

Reviewed by:
Dr. Sureshbabu Yadav
M.B.B.S., DIP.DIAB, F.R.S.H

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