Clonotril P 12.5mg/0.25mg Tablet

Last Updated: March 24th, 2026

Clonotril P 12.5mg/0.25mg Tablet is a product of Torrent Pharmaceuticals Ltd

Composition: Paroxetine (12.5mg) + Clonazepam (0.25mg)

₹ 101.09

Note: MRP can vary depending up on batch!

*MRP inclusive of all taxes

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All Details About Clonotril P 12.5mg/0.25mg Tablet

Find out detailed description, uses, directions of use, side effects, warnings and precautions, frequently asked questions about Clonotril P 12.5mg/0.25mg Tablet

Description:

Clonotril P 12.5mg/0.25mg Tablet is a prescription medicine used to treat depression. It is a combination medicine that works by increasing the level of chemical messengers in the brain that improve mood. It also calms the brain by decreasing the abnormal and excessive activity of the nerve cells.

Clonotril P 12.5mg/0.25mg Tablet can be taken with or without food. It is advised to take it at a fixed time each day to maintain a consistent level of medicine in the blood. Take this medicine in the dose and duration advised by your doctor, as it has habit-forming potential. Try to never skip any doses, but if you miss a dose of this medicine, take it as soon as you remember. Finish the full course of treatment even if you feel better. It is important not to stop taking this medicine suddenly, as it may result in withdrawal symptoms.

Some common side effects of this medicine include nausea, vomiting, confusion, memory impairment, low sexual desire, and delayed ejaculation. It may cause dizziness and sleepiness. So, do not drive or do anything that requires mental focus until you know how this medicine affects you. It is important to inform your doctor if you develop any unusual changes in mood or depression, as this medicine may cause suicidal thoughts.

Take caution while taking medicine if you are suffering from liver disease. Your doctor should also know about all other medicines you are taking, as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.

Uses:

Depression

Directions For Use:

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Clonotril P 12.5mg/0.25mg Tablet may be taken with or without food.

Side Effects:

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Ordinary side effects of Clonotril P

Nausea
Vomiting
Diarrhea
Confusion
Memory impairment
Uncoordinated body movements
Drowsiness
Fatiguedness
Anorgasmia (decreased orgasm)
Low sexual desire
Delayed ejaculation
Sleepiness
Dryness in mouth
Constipation

Warning & Precautions:

Alcohol

UNSAFE

Do not drink alcohol while you are taking this medicine. Clonotril P 12.5mg/0.25mg Tablet may cause excessive drowsiness when taken with alcohol.

Pregnancy

CONSULT YOUR DOCTOR

Clonotril P 12.5mg/0.25mg Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

UNSAFE

Clonotril P 12.5mg/0.25mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

Clonotril P 12.5mg/0.25mg Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Clonotril P 12.5mg/0.25mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Employ of Clonotril P 12.5mg/0.25mg Tablet can cause excessive sleepiness in patients with end stage kidney disease.

Liver

UNSAFE

Clonotril P 12.5mg/0.25mg Tablet is unsafe to use in patients with liver disease and should be avoided.

FAQs:

Are there any important warnings associated with the use of Clonotril P 12.5mg/0.25mg Tablet?

Clonotril P 12.5mg/0.25mg Tablet may increase suicidal thoughts or actions in some patients in the first few months of the treatment. Tolerants with mood or behavioral disorders have a high risk of suicidal thoughts and actions. You should pay close attention and report to your doctor any changes in behavior or mood. Make sure that you visit the doctor for the follow-up appointments as scheduled.

Can I stop taking Clonotril P 12.5mg/0.25mg Tablet when my symptoms are relieved?

No, you should continue taking Clonotril P 12.5mg/0.25mg Tablet even if you feel well. If you stop Clonotril P 12.5mg/0.25mg Tablet suddenly, serious withdrawal symptoms may occur. Your doctor will probably decrease your dose gradually.

How to manage weight gain associated with the use of Clonotril P 12.5mg/0.25mg Tablet?

Some reports suggest that the use of Clonotril P 12.5mg/0.25mg Tablet can cause weight gain. If you keep good eating habits and exercise regularly, you might not gain any weight. It is important to remember that it is easier to stop weight gain than to lose weight.

Can the use of Clonotril P 12.5mg/0.25mg Tablet cause sleepiness?

Affirmative, Clonotril P 12.5mg/0.25mg Tablet can make you feel sleepy. Avoid driving, operating machinery, working at heights, or participating in potentially dangerous activities until you know how this medicine affects you.

Can the use of Clonotril P 12.5mg/0.25mg Tablet affect my sex life?

The use of Clonotril P 12.5mg/0.25mg Tablet can affect the sexual life of both men and women. Divergent sexual problems can occur due to Clonotril P 12.5mg/0.25mg Tablet, like decreased sexual desire, erectile dysfunction (inability to develop or maintain an erection during sexual activity), and inability to reach orgasm. It can also cause a decrease in satisfaction and discomfort during intercourse. If you experience these problems, discuss them with your doctor.

Can I drink alcohol while taking Clonotril P 12.5mg/0.25mg Tablet?

No, do not drink alcohol while taking Clonotril P 12.5mg/0.25mg Tablet. Drinking alcohol can increase the severity of drowsiness or sleepiness caused by Clonotril P 12.5mg/0.25mg Tablet.

How long does Clonotril P 12.5mg/0.25mg Tablet take to work?

Everybody responds differently to treatment. In general, it can take several weeks to feel the full benefits of Clonotril P 12.5mg/0.25mg Tablet, although some people may start to feel better sooner. When taking Clonotril P 12.5mg/0.25mg Tablet, it is important to give it time to work.

What are the instructions for the storage and disposal of Clonotril P 12.5mg/0.25mg Tablet?

Retain this medicine in the packet or the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children, and other people.

Written by:
Dr. T. Sharmila Krishna
M.B.B.S., MD (Biochemistry)

Reviewed by:
Dr. Sureshbabu Yadav
M.B.B.S., DIP.DIAB, F.R.S.H

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