ACTEMRA 400 MG INJECTION 1.0 Injection in 1 vial

Last Updated: March 24th, 2026

ACTEMRA 400 MG INJECTION is a product of Roche Products India Pvt Ltd

Composition: Tocilizumab (400mg)

Pack of 1 injection

₹ 40545.00

Note: MRP can vary depending up on batch!

*MRP inclusive of all taxes

All Details About ACTEMRA 400 MG INJECTION

Find out detailed description, uses, directions of use, side effects, warnings and precautions, frequently asked questions about ACTEMRA 400 MG INJECTION

Description:

ACTEMRA 400 MG INJECTION is a medicine used to treat various inflammatory conditions of the joints (rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis), skin (psoriasis), and bowel (ulcerative colitis, Crohn’s disease). It reduces swelling in these conditions by blocking TNF alpha.

ACTEMRA 400 MG INJECTION is given by a healthcare professional and should not be self-administered. You should use it regularly and at the same time each day to get the maximum benefit from it. Continue using it as recommended by your doctor and complete the dose even if you feel better.

The most common side effects seen with this medicine include headache, high blood pressure, upper respiratory tract infection, increased liver enzymes, and nasopharyngitis (pain or irritation in the throat). Consult your doctor if any of the side effects persist or bother you. Your doctor may be able to help with ways to reduce or prevent these symptoms. You may also be more prone to infections when you are being treated with this medicine. Tell your doctor right away if you develop any symptoms of an infection like fever, cough, rash, loose stools, or flu-like symptoms.

To make sure the medicine is safe for you, before taking it, let your doctor know if you have any problems with your heart, kidneys, or liver. You should also tell your doctor about all the other medicines you are taking. While on treatment with this medicine, your doctor may monitor your blood counts by taking regular blood tests to make sure the medicine is not affecting your blood counts. It is important for pregnant and breastfeeding women to ask the advice of their doctors before taking this medicine.

Uses:

Directions For Use:

Your doctor or nurse will give you this medicine. Compassionately do not self administer.

Side Effects:

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Ordinary side effects of Actemra

Headache
High blood pressure
Upper respiratory tract infection
Injection site reactions (pain, swelling, redness)

Warning & Precautions:

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with ACTEMRA 400 MG INJECTION. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of ACTEMRA 400 MG INJECTION during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of ACTEMRA 400 MG INJECTION during breastfeeding is not available. Please consult your doctor.

Driving

CONSULT YOUR DOCTOR

It is not known whether ACTEMRA 400 MG INJECTION alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

CAUTION

ACTEMRA 400 MG INJECTION should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Limited information is available on the use of ACTEMRA 400 MG INJECTION in patients with moderate to severe kidney disease. No dose adjustment is required in patients with mild kidney disease.

Liver

CAUTION

ACTEMRA 400 MG INJECTION should be used with caution in patients with liver disease. Dose adjustment may be needed.
Employ of ACTEMRA 400 MG INJECTION is not recommended in patients with active liver disease.

FAQs:

Who should be treated with ACTEMRA 400 MG INJECTION?

ACTEMRA 400 MG INJECTION should be given for treating patients suffering from moderate to severe Covid-19 infection who have persistent reduction in their oxygen levels (a condition called hypoxia) that continues to get worse. The hypoxia may continue to get worsened even after 24 to 48 hours of treatment with corticosteroids and supportive care.

Is ACTEMRA 400 MG INJECTION recommended for all Covid-19 patients? If not, why?

No, ACTEMRA 400 MG INJECTION is not recommended for all Covid-19 patients. This is because ACTEMRA 400 MG INJECTION has its own potential health hazards. ACTEMRA 400 MG INJECTION can lead to persistent serious infection and prolonged multiplication and shedding of the virus causing infection, so, it must be given only if the benefits outweigh the risks involved.

What are the side effects of ACTEMRA 400 MG INJECTION?

The potential side effects of ACTEMRA 400 MG INJECTION include anaphylaxis (serious allergic reaction) with infusion, transaminitis (very high levels of liver enzymes due to which they start moving into the bloodstream), leukopenia (a condition where a person has reduced white blood cells and hence increased risk for infections) and neutropenia (a condition where a person has abnormally low number of cells called neutrophils, that fight infections in our body). Some other side effects are risk of serious bacterial infections, viral infections and reactivation of tuberculosis (TB) virus.

Who should not be given ACTEMRA 400 MG INJECTION?

ACTEMRA 400 MG INJECTION should not be given to patients who have or ever had abnormal levels of liver enzymes (transaminitis), platelet counts (<50000), or if they have TB, or any active bacterial or viral infection. The use of ACTEMRA 400 MG INJECTION is contraindicated in pregnancy and breastfeeding mothers too, owing to its risk of developing serious complications.

What to do if there is no improvement seen after giving ACTEMRA 400 MG INJECTION too?

Your doctor will decide the next course of action if there is no improvement seen even after giving ACTEMRA 400 MG INJECTION. ACTEMRA 400 MG INJECTION will prevent inflammation of the lungs but will not cure the damage already done due to the existing disease. Recovery of the lungs takes time to improve. Persistent breathlessness after ACTEMRA 400 MG INJECTION administration requires further evaluation of patients for other lung-related issues (pulmonary intravascular coagulopathy) or heart-related problems (cardiac dysfunctions). Any other bacterial infections that might have occurred should also be treated separately.

Written by:
Dr. T. Sharmila Krishna
M.B.B.S., MD (Biochemistry)

Reviewed by:
Dr. Sureshbabu Yadav
M.B.B.S., DIP.DIAB, F.R.S.H

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